Tottenham will look to consolidate second position today when they welcome a Southampton side in pursuit of European football to White Hart Lane.
Kick-off there is at 1.30.
At 4pm, Manchester City can climb to third in the league if they beat Arsenal at the Emirates Stadium.
Manuel Pellegrini's side will need a result if they are to ensure they have Champions League football next season with the arrival of Pep Guardiola.
It's Pellegrini's last home game with Manchester City.
Also at 4:00, Liverpool host Watford.
The visitors won the reverse fixture earlier this season, 3-0 at Vicarage Road but Jurgen Klopp will look for an energised performance after the Reds qualified for the Europa League final on Thursday night.
Meanwhile, Celtic need just a point today to be confirmed as Scottish Premiership champions once again.
They host Aberdeen – who are the only team still in with a chance of claiming the title.
Their opponents are 9 points behind with 3 games to go, though a vastly inferior goal-difference means Celtic are highly likely to claim top spot regardless.