Keith Earls is to make his first start of the season for Munster's final pool 1 game with Sale.
He'll partner Denis Hurley in the centre, with Pat Howard dropping to the replacements bench.
With Felix Jones out with a bruised knee, Simon Zebo moves to full-back, and Ronan O'Mahoney makes his first start on the wing.
In the back-row, Dave O'Callaghan is in at blindside, Tommy O'Donnell stays at openside and captain Peter O'Mahony moves to number 8 in place of the injured CJ Stander.
Munster can't qualify for the knockout stages after losing to Saracens last time out, and Head coach Anthony Foley says
it's been a difficult week for the province