Keith Earls and Robbie Henshaw have been paired in the Ireland midfield for Sunday's meeting with Italy at the Olympic stadium.
Tommy Bowe and Dave Kearney are on the wings with Simon Zebo at full back and Sexton and Murray in the half backs.
Jack Mc Grath gets the nod ahead of Cian Healy in the front row along with Rory Best and Mike Ross.
Iain Henderson and Paul O'Connell are in the second row with O'Mahony, O'Brien and Heaslip in the back row.
The team in full is:
15. Simon Zebo (Cork Constitution/Munster)
14. Tommy Bowe (Belfast Harlequins/Ulster)
13. Keith Earls (Young Munster/Munster)
12. Robbie Henshaw (Buccaneers/Connacht)
11. Dave Kearney (Lansdowne/Leinster)
10. Johnny Sexton (St Mary's College/Leinster)
9. Conor Murray (Garryowen/Munster)
1. Jack McGrath (St Mary's College/Leinster)
2. Rory Best (Banbridge/Ulster)
3. Mike Ross (Clontarf/Leinster)
4. Iain Henderson (Ballynahinch/Ulster)
5. Paul O'Connell (Young Munster) captain
6. Peter O'Mahony (Cork Constitution/Munster)
7. Sean O'Brien (UCD/Leinster)
8. Jamie Heaslip (Dublin University/Leinster)
Replacements
16. Sean Cronin (St. Mary's College/Leinster)
17. Cian Healy (Clontarf/Leinster)
18. Nathan White (Connacht)
19. Devin Toner (Lansdowne/Leinster)
20. Chris Henry (Malone/Ulster)
21. Eoin Reddan (Old Crescent/Leinster)
22. Ian Madigan (Blackrock College/Leinster)
23. Luke Fitzgerald (Blackrock College/Leinster)
